Sequence-derived structural features driving proteolytic processing
نویسندگان
چکیده
منابع مشابه
Proteolytic processing of tau.
Tau aggregation is a hallmark of several neurodegenerative diseases, including AD (Alzheimer's disease), although the mechanism underlying tau aggregation remains unclear. Recent studies show that the proteolysis of tau plays an important role in both tau aggregation and neurodegeneration. On one hand, truncation of tau may generate amyloidogenic tau fragments that initiate the aggregation of t...
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ژورنال
عنوان ژورنال: PROTEOMICS
سال: 2013
ISSN: 1615-9853
DOI: 10.1002/pmic.201300416